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Áٱ⼼Æ÷¹ß»ýÇÐ ½ÇÇè½Ç, BRIC Biolab¿¡ ¼Ò°³
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   https://www.ibric.org/myboard/read.php?Board=biolab&id=3571 [697]
Áٱ⼼Æ÷¹ß»ýÇÐ ½ÇÇè½Ç, BRIC Biolab¿¡ ¼Ò°³µÇ¾ú½À´Ï´Ù.

BioWave  Vol. 25 No. 2µî·Ï 2022.10.17 
°Ç±¹´ëÇб³ Áٱ⼼Æ÷Àç»ý°øÇаú Áٱ⼼Æ÷ ¹ß»ýÇÐ ¿¬±¸½ÇµµÁ¤Å ±³¼ö
¿¬±¸½Ç ȨÆäÀÌÁö
Introduction 
 

 ÀúÈñ Áٱ⼼Æ÷¹ß»ýÇבּ¸½ÇÀº ¸¸´ÉÁٱ⼼Æ÷ Çü¼º ±â¼úÀ» ÀÌ¿ëÇÑ Àΰ£ À¯µµ¸¸´ÉÁٱ⼼Æ÷(iPS cells)À» ÀÌ¿ëÇÑ Áúº´¿¬±¸, Áٱ⼼Æ÷ÀÇ ºÐÈ­´É ¿¬±¸¸¦ ÅëÇÑ ½Å°æ¼¼Æ÷¼¼Æ÷ ¶Ç´Â ¹Ì´Ï ³úÁ¶Á÷(³ú¿À°¡³ëÀ̵å, brain organoids) Çü¼º ¹× ÀÀ¿ë ¿¬±¸, ¹è¾Æ ¹ß»ý°úÁ¤À» ¿¬±¸Çϱâ À§ÇÑ ÇÕ¼º¹è¾Æ(synthetic embryo) ¿¬±¸, Áٱ⼼Æ÷ ¹è¾çÀ» ÅëÇÑ ¹è¾çÀ°(cultured meat) »ý»ê ¿¬±¸¸¦ ÇÏ°í ÀÖ½À´Ï´Ù. ÀÌ¿Ü¿¡ ¹ÌÅäÄܵ帮¾Æ º¯È­ ¹× ¹ÌÅäÄܵ帮¾Æ ´ë»ç, ÈÄ»ýÀ¯ÀüÀ» Æ÷ÇÔÇÑ ¿©·¯ °¡Áö Çö»óÀ» ¿¬±¸ÇÏ°í ÀÖ½À´Ï´Ù. ƯÈ÷, ü¼¼Æ÷ ¸®ÇÁ·Î±×·¡¹Ö¿¡ ÀÇÇÑ ¸¸´É¼º ȹµæ¿¡ °üÇÑ ¿¬±¸¸¦ ±â¹ÝÀ¸·Î Çü¼ºµÈ ´Ù¾çÇÑ Áٱ⼼Æ÷ (À¯µµ¸¸´ÉÁٱ⼼Æ÷, È®Àå ¸¸´ÉÁٱ⼼Æ÷, À¶ÇÕ¸¸´ÉÁٱ⼼Æ÷ µî) »ý»ê ±â¼úÀ» È®º¸ÇÏ°í ÀÖ½À´Ï´Ù.

  Prof. Jeong-Tae Do
  °Ç±¹´ëÇб³, KUÀ¶ÇÕ°úÇбâ¼ú¿ø(KIT), Áٱ⼼Æ÷Àç»ý°øÇаú

  Education and Training
   Çлç: °Ç±¹´ëÇб³ µ¿¹°»ý¸í°øÇÐ
   ¼®»ç: °Ç±¹´ëÇб³ ¹ß»ý°øÇÐ
   ¹Ú»ç: °Ç±¹´ëÇб³ ¹ß»ý°øÇÐ

  Professional Experiences
  2017  ~ ÇöÀç  °Ç±¹´ëÇб³ KUÀ¶ÇÕ°úÇбâ¼ú¿ø, Áٱ⼼Æ÷Àç»ý°øÇаú, ºÎ±³¼ö, ±³¼ö
  2012  ~ 2017  °Ç±¹´ëÇб³ µ¿¹°»ý¸í°úÇдëÇÐ, µ¿¹°»ý¸í°øÇаú, Áٱ⼼Æ÷Àç»ý»ý¹°Çаú, Á¶±³¼ö, ºÎ±³¼ö
  2009.01 ~ 2012.08  CHA ÀÇ°úÇдëÇб³, ÀÇ»ý¸í°úÇаú Á¶±³¼ö

 
Research 
 

 (1) ¼¼Æ÷ ¸®ÇÁ·Î±×·¡¹ÖÀ» ÅëÇÑ ¾ÈÀüÇÑ À¯µµ¸¸´ÉÁٱ⼼Æ÷ ±â¼ú °³¹ß(ȯÀÚ À¯µµ¸¸´ÉÁٱ⼼Æ÷ ÀÌ¿ëÇÑ Áúȯ ¿¬±¸)
  ¡Ü Æ÷À¯·ù¿¡¼­ÀÇ Ã¼¼¼Æ÷ ¿ªºÐÈ­´Â 1997³â ÃÖÃÊÀÇ Ã¼¼¼Æ÷ º¹Á¦¾ç 'µ¹¸®¡®ÀÇ Åº»ý¿¡ ÀÇÇØ ÀÔÁõµÇ¾ú´Ù.
  ¡Ü ¶Ç ´Ù¸¥ ¹æ¹ýÀº, ü¼¼Æ÷°¡ ¹è¾ÆÁٱ⼼Æ÷¿Í À¶ÇյǾî ÇϳªÀÇ ¼¼Æ÷°¡ µÇ¸é, ü¼¼Æ÷ÀÇ ÇÙÀº ¿ªºÐÈ­¸¦ °ÅÃÄ ¸¸´É¼ºÀ» ȹµæÇÏ¿© ¹è¾ÆÁٱ⼼Æ÷ÀÇ Æ¯Â¡
  À» ȹµæ ÇϰԵȴÙ. ¼¼Æ÷À¶ÇÕ¿¡ ÀÇÇÑ ¿ªºÐÈ­´Â 24-48½Ã°£³»¿¡ ÀϾ´Â ¸Å¿ì ºü¸£°í È¿À²ÀûÀÎ ¿ªºÐÈ­ ¹æ¹ýÀ¸·Î ¿ªºÐÈ­¿¡ ÇÊ¿äÇÑ ÀÎÀÚ ¹× ±âÀü ¿¬±¸¿¡
  »ç¿ëµÇ°í ¿Ô´Ù.
  ¡Ü 2006³â¿¡´Â ÀϺ» ¾ß¸¶³ªÄ« ±³¼öÆÀÀÌ ¹è¾ÆÁٱ⼼Æ÷ÀÇ µµ¿òÀÌ ¾øÀÌ ³× °¡ÁöÀÇ Àü»çÀÎÀÚ(ÇÙ³» Á¸ÀçÇÏ´Â ÀÎÀÚ), Oct4, Sox2, Klf4, c-Myc ¸¸À¸·Î ºÐÈ­
  µÈ ü¼¼Æ÷¸¦ ¹è¾ÆÁٱ⼼Æ÷¿Í µ¿ÀÏÇÑ ÇüÅÂ¿Í ´É·ÂÀ» Áö´Ñ ¿ªºÐÈ­ ¸¸´ÉÁٱ⼼Æ÷(induced pluripotent stem cells)¸¦ ¼ö¸³ÇÏ¿´´Ù (Takahashi and
  Yamanaka, 2006). ¹è¾Æ¸¦ »ç¿ëÇÏÁö ¾Ê´Â À¯µµ¸¸´ÉÁٱ⼼Æ÷´Â À±¸®Àû ¹®Á¦ ¾øÀÌ »ý»êÀÌ °¡´ÉÇÑ ¸¸´ÉÁٱ⼼Æ÷·Î ´Ù¾çÇÑ ºÐ¾ß¿¡ »ç¿ëµÉ ¼ö ÀÖ´Ù.
  ¡Ü Ãʱ⿡´Â À¯µµ¸¸´ÉÁٱ⼼Æ÷ »ý»êÀ» À§ÇØ ¼¼Æ÷¿¡ ¿Ü·¡ À¯ÀüÀÚ°¡ »ðÀԵǴ ·»Æ¼¹ÙÀÌ·¯½º ¶Ç´Â ·¹Æ®·Î ¹ÙÀÌ·¯½º¸¦ »ç¿ëÇÏ¿´À¸¸¶, ÇöÀç´Â ¿Ü·¡ À¯Àü
  ÀÚ°¡ »ðÀÔµÇÁö ¾Ê´Â ´Ù¾çÇÑ ¹æ¹ýÀÌ °³¹ßµÇ¾î ÀÓ»ó Àû¿ëÀÌ °¡´ÉÇÑ ¾ÈÀüÇÑ À¯µµ¸¸´ÉÁٱ⼼Æ÷ »ý»êÀÌ °¡´ÉÇÏ´Ù. º» ½ÇÇè½Ç¿¡¼­µµ ´Ù¾çÇÑ ¹æ¹ýÀ» ÀÌ¿ëÇÑ
  ¿Ü·¡À¯ÀüÀÚ »ðÀÔ¾ø´Â À¯µµ¸¸´ÉÁٱ⼼Æ÷ »ý»ê±â¼úÀ» È®º¸ÇÏ°í ÀÖ´Ù.
  ¢¹ ³ª³ëÆ©ºê(nanotube)¿Í ´Ü¹éÁú(Oct4, Sox2, c-Myc, Klf4, Nanog)À» ÀÌ¿ëÇÑ ¸®ÇÁ·Î±×·¡¹Ö
  ¢¹ Çö󽺹̵带 ÀÌ¿ëÇÑ ¸®ÇÁ·Î±×·¡¹Ö À¯ÀüÀÚ transfectionÀ» ÅëÇÑ ¸®ÇÁ·Î±×·¡¹Ö
  ¢¹ ¼¾´ÙÀ̹ÙÀÌ·¯½º¸¦ ÀÌ¿ëÇÑ ¿Ü·¡À¯ÀüÀÚ »ðÀÔ¾ø´Â À¯µµ¸¸´ÉÁٱ⼼Æ÷ »ý»ê ¸®ÇÁ·Î±×·¡¹Ö ±â¹ý
  ¡Ü ÇÁ·¡´õÀª¸®ÁõÈıº, ·¹Æ®ÁõÈıº µîÀÇ ³úÁúȯ ȯÀÚÀÇ ¼¼Æ÷¸¦ ÀÌ¿ëÇÑ È¯ÀÚ À¯µµ¸¸´ÉÁٱ⼼Æ÷¸¦ ¼ö¸³ÇÏ¿©, ³úÁúȯ ¿¬±¸¸¦ ÇÏ°í ÀÖ´Ù.

 (2) ³ú¿À°¡³ëÀ̵å(Brain Organoid)
  ¡Ü 1907³â °³±¸¸® Ãʱ⠹è¾Æ¿¡¼­ ´º·ÐÀ» ¹è¾çÇÑ °ÍÀ» ½ÃÀÛÀ¸·Î, ÀÌÈÄ ¼ºÃ¼ ³ú·ÎºÎÅÍ ½Å°æÁٱ⼼Æ÷¸¦ ¹è¾çÇÒ ¼ö ÀÖÀ½À» ¹àÇôÁö°í, neurosphereÇüÅÂ
  ·Î ½Å°æÁٱ⼼Æ÷¸¦ À¯ÁöÇÏ´Â ±â¼úÀÌ °³¹ßµÇ¾ú´Ù. ÇÏÁö¸¸, ÃÖ±Ù¿¡´Â 3Â÷¿ø ³úÁ¶Á÷À» ¸ð»çÇÏ´Â, Á¶Á÷ÇüÅÂÀÇ ¹è¾ç ½Ã½ºÅÛÀÎ ³ú¿À°¡³ëÀÌµå ¿¬±¸°¡ È°¹ß
  È÷ ÁøÇàµÇ°í ÀÖ´Ù. Áٱ⼼Æ÷¹ß»ýÇÐ ¿¬±¸½Ç¿¡¼­´Â Àΰ£ À¯µµ¸¸´ÉÁٱ⼼Æ÷¸¦ ÀÌ¿ëÇÏ¿© Àΰ£ ³ú¿À°¡³ëÀÌµå ¸¸µé°í, À̸¦ ÀÌ¿ëÇÑ ³úÁúȯ ¿¬±¸¸¦ ¼öÇà
  ÇÏ°í ÀÖ´Ù.
  ¡Ü Àü³ú, Áß³ú, ÈÄÅð ¹× ½Ã°¢ Á¶Á÷À» Æ÷ÇÔÇÏ´Â whole-brain organoid ¹è¾çÀÌ °¡´ÉÇϸç, ¿¬±¸ ¸ñÀû¿¡ µû¶ó Àüü ¶Ç´Â ÀϺΠ³úÁ¶Á÷ ¹è¾çÀÌ °¡´ÉÇÏ´Ù.
  ¡Ü ¿°±¤¿°»öÀ¸·Î È®ÀÎÇÑ °á°ú ¾ÈÂÊÀº ½Å°æÁٱ⼼Æ÷(Sox2+), ¹Ù±ùÂÊÀº ºÐÈ­µÈ ½Å°æ¼¼Æ÷ÃþÀ» Çü¼ºÇÏ°í ÀÖ´Â ¿À°¡³ëÀ̵尡 Çü¼ºµÈ´Ù. À̸¦ ±âÃÊ·Î ÇÏ
  ¿©, ´Ù¾çÇÑ ³úÁúȯ ȯÀÚ ³ú¿À°¡³ëÀ̵带 ÀÌ¿ëÇÑ 3Â÷¿ø ±¸Á¶¿¡¼­ÀÇ ÁúȯÀ» ¿¬±¸ÇÏ°í ÀÖ´Ù.

 (3) ÇÕ¼º ¹è¾Æ (Synthetic embryo) ¹× Àڱ󻸷 ¿À°¡³ëÀ̵å
  ¡Ü Æ÷À¯·ù ¹ß»ýÇÐ ¿¬±¸¿¡ ÀÖ¾î, ³­ÀÚ¿Í Á¤ÀÚ ¹× ¼öÁ¤¶õ ¿¬±¸´Â ¸Å¿ì ±âº»ÀûÀÎ ¿¬±¸´Ù. ÇÏÁö¸¸, ³­ÀÚ, Á¤ÀÚ, ¼öÁ¤¶õ ¿¬±¸´Â Àΰ£¿¡ ÀÖ¾î »ý¸íÀ±¸®¹ý¿¡
  ¾ö°ÝÈ÷ Àû¿ë ¹Þ´Â ºÐ¾ß·Î Àΰ£¿¡¼­ÀÇ ¿¬±¸°¡ ¸Å¿ì Á¦ÇÑÀûÀÌ´Ù.
  ¡Ü ¸¸¾à, ÀΰøÀûÀ¸·Î ¼öÁ¤¶õÀ» »ý»êÇÒ ¼ö ÀÖ´Ù¸é, À±¸®Àû Á¦ÇÑÀÌ ¾øÀÌ ¹è¾Æ¹ß´Þ ¿¬±¸°¡ °¡´ÉÇÏ´Ù.
  ¡Ü ÃÖ±Ù ÇÕ¼º¹è¾Æ(Synthetic embryo, ¶Ç´Â Embryoid) ±â¼úÀÌ °³¹ßµÇ¾î, Àΰ£¿¡¼­ÀÇ ¹è¾Æ¹ß´Þ ¿¬±¸ Àû¿ëÀÌ ¸ÓÁö ¾Ê¾Æ °¡´ÉÇÒ °ÍÀ¸·Î ¿¹ÃøµÈ´Ù.
  ¡Ü Áٱ⼼Æ÷¹ß»ýÇÐ ¿¬±¸½Ç¿¡¼­´Â Âø»óÀü ´Ü°èÀÇ ¹è¾ÆÀÎ ¹è¹ÝÆ÷(blastocyst)¸¦ ÇÕ¼ºÇϱâÀ§ÇØ, ¹è¹ÝÆ÷¸¦ ±¸¼ºÇÏ´Â 3°¡Áö ¼¼Æ÷ÃþÀÎ epiblast, primitive
  endoderm, trophectoderm¿¡¼­ À¯·¡µÈ Áٱ⼼Æ÷ ES cells, XEN cells, trophoblast stem cellsÀ» ¼ö¸³ÇÏ°í À̸¦ ÀÌ¿ëÇÑ ÇÕ¼º ¹è¹ÝÆ÷(Blastoid)¿Í Âø»óÈÄ
  ¹è¾ÆÀÎ ETX embryo ¿¬±¸¸¦ ÇÏ°í ÀÖ´Ù. ¾ÆÁ÷ »ýÁ㸦 ÀÌ¿ëÇÑ ¿¬±¸ÀÌÁö¸¸, Àΰ£ Áٱ⼼Æ÷¸¦ ÀÌ¿ëÇÑ ¿¬±¸µµ °ð ¼öÇàÇÒ ¿¹Á¤ÀÌ´Ù.

 (4) ¹è¾çÀ° (Ceultured meat)
  ¡Ü ¹è¾çÀ°Àº °¡ÃàÀ» »ç¾çÇϰųª µµÃàÇÏÁö ¾Ê°í, ½ÇÇè½Ç¿¡¼­ ±ÙÀ°Áٱ⼼Æ÷¸¦ ¹è¾çÇÏ¿© ¸¸µç °í±âÀÌ´Ù. µû¶ó¼­, ¹è¾çÀ°Àº ±âÁ¸ À°·ù »ý»ê´ëºñ ¿Â½Ç
  °¡½º ¹èÃâ·® 80% °¨¼Ò, ÅäÁö »ç¿ë·® 99% Àý°¨, ´ã¼ö »ç¿ë·® 96% Á¡°¨ÀÌ °¡´ÉÇÑ Ä£È¯°æ »ý¸í°øÇÐ ±â¼úÀÌ´Ù. 2040³â¿¡´Â ¹è¾çÀ°ÀÌ ¼¼°è À°·ù¼Òºñ·®
  ÀÇ 35%¸¦ Â÷ÁöÇÒ °ÍÀ¸·Î ¿¹ÃøµÈ´Ù.
  ¡Ü ¹è¾çÀ°¸¦ »ý»êÇϱâÀ§Çؼ­´Â ´Ù¾çÇÑ Áٱ⼼Æ÷¿Í 3Â÷¿ø ±¸Á¶¸¦ Çü¼ºÇϱâÀ§ÇÑ ÁöÁöü ¹× 3Â÷¿ø ¹è¾ç ±â¼úÀÌ ÇÊ¿äÇÏ´Ù.
  ¡Ü Áٱ⼼Æ÷¹ß»ýÇÐ ¿¬±¸½Ç¿¡¼­´Â ¼Ò, µÅÁö, ´ß¿¡¼­ÀÇ ±ÙÀ°Áٱ⼼Æ÷, Áö¹æÁٱ⼼Æ÷, °áüÁ¶Á÷À» ¼ö¸³ÇÏ¿´À¸¸ç, ¼Ò, µÅÁö, ´ß¿¡¼­ ¸¸´ÉÁٱ⼼Æ÷(ES cells,
  iPS cells, extended potential stem cells)¸¦ ¼ö¸³ÇÏ¿© ±ÙÀ°¼¼Æ÷ ¹× Áö¹æ¼¼Æ÷·ÎÀÇ ºÐÈ­ ¿¬±¸¸¦ ÁøÇàÁßÀÌ´Ù.
  ¡Ü ÃÖ±Ù, ¹è¾çÀ° º¥Ã³È¸»çÀÎ ³Ø½ºÆ®ÇªµåÅ×Å©(NEXT Food Tech)¸¦ ¼³¸³ÇÏ¿©, ¹è¾çÀ°ÀÇ »ê¾÷È­¸¦ À§ÇØ ¿¬±¸¸¦ ÁøÇàÁßÀÌ´Ù.

 

 (5) ¹ÌÅäÄܵ帮¾Æ¿Í Áúȯ°úÀÇ ¿¬°ü¼º ¿¬±¸
  ¡Ü ¹ÌÅäÄܵ帮¾Æ´Â ÀÚüÀÇ À¯Àü¹°ÁúÀ» °¡Áö°í ÀÖÀ¸¸ç, ¼¼Æ÷ÀÇ »ýÁ¸¿¡ °ü°èµÇ´Â ´ë»ç¿¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â ¼¼Æ÷³» ¼Ò±â°üÀ̸ç, ¹ÌÅäÄܵ帮¾Æ ±â´ÉÀÇ
  °¨¼Ò´Â ¼¼Æ÷ÀÇ ³ëÈ­, ¾Ï, ½Å°æ°è Áúȯ, ±ÙÀ° ±â´É ¾àÈ­, °£ ±â´É ¾àÈ­ µî ´Ù¾çÇÑ Á¶Á÷ ¼¼Æ÷¿¡ ¿µÇâÀ» ¹ÌÄ¡°í ÀÖ´Â °ÍÀ¸·Î ¾Ë·ÁÁ® ÀÖ´Ù.
  ¡Ü ¹ÌÅäÄܵ帮¾Æ´Â fusion°ú fissionÀ» ¹Ýº¹Çϸ鼭 ¼¼Æ÷ ³»¿¡¼­ ¹ÌÅäÄܵ帮¾ÆÀÇ ÇüÅ º¯È­¸¦ ÀÏÀ¸Å´À¸·Î½á, ¼¼Æ÷ ŸÀÔ¿¡ µû¶ó ¹ÌÅäÄܵ帮¾ÆÀÇ º¯ÇüÀ»
  ÅëÇÑ °¢ ¼¼Æ÷ÀÇ ´ë»ç º¯È­¿¡ ¿µÇâÀ» ÁÖ¸ç, ¹ÌÅäÄܵ帮¾Æ´Â ¼¼Æ÷ÀÇ ºÐÈ­ °úÁ¤°ú ¸Å¿ì ¹ÐÁ¢ÇÑ °ü°è°¡ ÀÖÀ½À» ³ªÅ¸³»°í ÀÖ´Ù.
  ¡Ü ¶ÇÇÑ ÅðÇ༺ ½Å°æÁúȯÀÎ ¾ËÃ÷ÇÏÀ̸Ó, ÆÄŲ½¼, ÇåÆÃÅÏ ÁúȯÀÇ °æ¿ì ¸ðµÎ ¹ÌÅäÄܵ帮¾ÆÀÇ ÀÌ»óÀÌ °üÂûµÇ°í ÀÖÀ¸¸ç, ¹ÌÅäÄܵ帮¾Æ ÇüÅ º¯È­¿¡ °ü·Ã
  µÈ À¯ÀüÀÚ Drp1, Mfn2, Opa1µîÀÇ À¯ÀüÀÚ ¹ßÇöÀÌ ¼¼Æ÷ÀÇ ³ëÈ­, ¾Ï, ½Å°æÁúȯ °ü·Ã ´Ü¹éÁú°úÀÇ ¿¬°ü°ü°è°¡ ÀÖ´Â °ÍÀ¸·Î º¸°íµÇ°í ÀÖ´Ù.
  ¡Ü º» ½ÇÇè½Ç¿¡¼­´Â ´Ù¾çÇÑ Áٱ⼼Æ÷¿¡¼­ÀÇ ¹ÌÅäÄܵ帮¾Æ ÇüÅ ¹× ¹ÌÅäÄܵ帮¾Æ ´ë»ç¿¡ ´ëÇÑ ±âÃÊ ¿¬±¸ ¹× ÅðÇ༺ ½Å°æÁúȯ¿¡¼­ÀÇ ¹ÌÅäÄܵ帮¾Æ
  ¿¬°ü¼º ¿¬±¸¸¦ ÅëÇØ ½Å°æÁúȯ ȯÀÚ¿¡¼­ÀÇ ¹ÌÅäÄܵ帮¾ÆÀÇ º¯È­ °ü·Ã À¯ÀüÀÚÀÇ Áúȯ°úÀÇ ¿¬°ü¼º¿¡ ´ëÇÑ ¿¬±¸¸¦ ÇÏ°í ÀÖ´Ù.

 (6) Áٱ⼼Æ÷ÀÇ ÈļºÀ¯Àü (Epigenetics in stem cells)
  ¡Ü ÈļºÀ¯ÀüÀ̶õ, À¯ÀüÀÚÀÇ DNAÀÇ º¯È­ ¾øÀÌ À¯ÀüÀÚÀÇ ¹ßÇöÀ» Á¶ÀýÇϸç, ¼¼Æ÷°¡ ºÐ¿­Çϸ鼭µµ µþ¼¼Æ÷¿¡µµ ÀüÀÌ°¡ µÇ´Â Çö»óÀ» ¸»ÇÑ´Ù. DNA ¸ÞÆ¿È­,
  È÷½ºÅæ ¸ÞÆ¿È­ ¹× ¾Æ¼¼Æ¿È­, X chromosomeÀÇ È°¼ºÈ­, °¢ÀÎ À¯ÀüÀÚÀÇ º¯È­ µîÀÌ ÀÌ¿¡ ¼ÓÇÑ´Ù. ÈļºÀ¯ÀüÀ» ÀÌÇØÇÏ´Â °ÍÀÌ À¯ÀüÀÚ ¹ßÇöÀ» ÀÌÇØÇÏ´Â °¡Àå ±Ùº»ÀûÀÎ ±âÀü ¿¬±¸ÀÇ ¹æÇâÀÌ µÈ´Ù. µû¶ó¼­, Áٱ⼼Æ÷ ¹× ¼¼Æ÷¿ªºÐÈ­ °úÁ¤À» ÀÌÇØÇÔÀ¸·Î½á »ý¸í Çö»ó¿¡ °üÇÑ ±âÃÊ Á¤º¸¸¦ Á¦°øÇÒ ¼ö ÀÖÀ» »Ó¸¸ ¾Æ´Ï
  ¶ó, ÀÌ·¯ÇÑ ±âÃÊ Á¤º¸¸¦ ÅëÇØ Áٱ⼼Æ÷°¡ »ç¶÷À» Ä¡·áÇϱâÀ§ÇÑ Àç·á·Î½á ¾ÈÀüÇÏ´Ù´Â °ÍÀ» Áõ¸íÇÒ ¼ö ÀÖÀ» °ÍÀÌ´Ù.
  ¡Ü º» ¿¬±¸½Ç¿¡¼­´Â ¼¼Æ÷ ¿ªºÐÈ­ °úÁ¤¿¡¼­ÀÇ DNA ¸ÞÆ¿È­, °¢ÀÎ À¯ÀüÀÚ º¯È­, X ¿°»öü ºÒÈ°¼ºÈ­ ¿¬±¸¸¦ ¼öÇàÇÏ°í ÀÖ´Ù.

 
Publications 
 

ÃÖ±Ù 3³â, 2020~2022

 - 2022
Kim SM, Kwon EJ, Kim YJ, Go YH, Oh JY, Park S, Do JT, Kim KT, Cha HJ.Dichotomous role of Shp2 for na?ve and primed pluripotency maintenance in embryonic stem cells. Stem Cell Res Ther. 2022 Jul 18;13(1):329. doi: 10.1186/s13287-022-02976-z.

La H, Yoo H, Park YB, Thang NX, Park C, Yoo S, Lee H, Choi Y, Song H, Do JT, Hong K. Role of Transcriptional and Epigenetic Regulation in Lymphatic Endothelial Cell Development. Cells. 2022 May 19;11(10):1692. doi: 10.3390/cells11101692.

Choi EH, Yoon S, Koh YE, Hong TK, Do JT, Lee BK, Hahn Y, Kim KP. (2022.03.03.). Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes. Genome Biology. 23(1):70. doi: 10.1186/s13059-022-02632-y.

Hong YJ, Lee SB, Choi J, Yoon SH, Do JT. (2022.02.28.). A Simple Method for Generating Cerebral Organoids from Human Pluripotent Stem Cells. International Journal of Stem Cells. 15(1):95-103. doi: 10.15283/ijsc21195

 - 2021

Kang M, Ahn B, Youk S, Cho HS, Choi M, Hong K, Do JT, Song H, Jiang H, Kennedy LJ, Park C. (2021. 07. 13) High Allelic Diversity of Dog Leukocyte Antigen Class II in East Asian Dogs: Identification of New Alleles and Haplotypes. Journal of Mammalian Evolutionthis. 28(2):773-784. doi: 10.1007/s10914-021-09560-x.

Lee J, Park H, Moon S, Do JT, Hong K, Choi Y. (2021. 8. 30). expression and Regulation of CD73 during the Estrous Cycle in Mouse Uterus. International Journal of Molecular Science. 22(17):9403. doi: 10.3390/ijms22179403.

Sang Hoon Yoon, Mi Rae Bae, Hyeonwoo La, Hyuk Song, Kwonho Hong and Jeong Tae Do. (2021. 8. 3). Efficient generation of neural stem cells from embryonic stem cells using a three-dimensional differentiation system. International Journal of Molecular Science. 22(15):8322. doi.org/10.3390/ijms22158322.

Hong TK, Song JH, Lee SB, Do JT. (2021. 7. 26). Germ cell derivation from pluripotent stem cells for understanding in vitro gametogenesis. Cells. 10(8):1889. doi.org/10.3390/cells10081889.

Kim J, Baek S, Hong YJ, de Paula MN, Jahan Prima M, Oh YM, Cha SS, Do JT, Jang YJ, Choe H. (2021. 5. 31). DJ-1 Can Replace FGF-2 for Long-Term Culture of Human Pluripotent Stem Cells in Defined Media and Feeder-Free Condition. International Journal of Molecular Science. 22(11):5954. doi: 10.3390/ijms22115954.

Hong TK, Shin DM, Choi J, Do JT*, Han SG*. (2021. 5. 1) Current issues and technical advances in cultured meat production: a review. Food Science of Animal Resource. 41(3):355-372. doi: 10.5851/kosfa.2021.e14. *co-corresponding authors.

Park HJ, Lee WY, Do JT, Park C, Song H. (2021. 5. 1.). Evaluation of testicular toxicity upon fetal exposure to bisphenol A using an organ culture method. Chemosphere. 270:129445. doi: 10.1016/j.chemosphere.2020.129445.

Han MJ, Lee WJ, Choi J, Hong YJ, Uhm SJ, Choi Y, Do JT. (2021. 2. 1). Inhibition of neural stem cell aging through the transient induction of reprogramming factors. Journal of Comparative Neurology. 529(3):595-604. doi: 10.1002/cne.24967.

 - 2020
Won Ji Lee, Jeong Eon Lee, Yean Ju Hong, Sang Hoon Yoon, Hyuk Song, Chankyu Park, Kwonho Hong, Youngsok, Choi, Jeong Tae, Do. (2020. 12. 1). Generation of brain organoids from mouse ESCs via teratoma formation. Stem Cell Research. 49:102100. doi:10.1016/j.scr.2020.102100

Ryu MJ, Seo BJ, Choi YJ, Han MJ, Choi Y, Chung MK, Do JT. (2020. 11. 1). Mitochondrial and Metabolic Dynamics of Endometrial Stromal Cells During the Endometrial Cycle. Stem Cells and Development 29(21):1407-1415. doi: 10.1089/scd.2020.0130.

Gurunathan S, Qasim M, Choi Y, Do JT, Park C, Hong K, Kim JH, Song H. (2020. 8. 21). Antiviral Potential of Nanoparticles-Can Nanoparticles Fight Against Coronaviruses? Nanomaterials. 10(9):1645. doi: 10.3390/nano10091645.

Seo BJ, Choi J, La H, Babib O, Choi Y, Hong K, Do JT. (2020. 9. 1). Role of mitochondrial fission-related genes in mitochondrial morphology and energy metabolism in mouse embryonic stem cells. Redox Biology. 36:101599. doi: 10.1016/j.redox.2020.101599

Park HJ, Zhang M, Lee WY, Hong KH, Do JT, Park C, Song H. (2020. 5. 15). Toxic Effects of Nonylphenol on Neonatal Testicular Development in Mouse Organ Culture. International Journal of Molecular Science. 21(10):E3491. doi: 10.3390/ijms21103491.

Yoon SH, Choi J, Lee WJ, Do JT. (2020. 3. 31). Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder. Journal of Clininical Medicine. 9(4):966. doi: 10.3390/jcm9040966.

Choi J, Seo BJ, La H, Yoon SH, Hong YJ, Lee JH, Chung HM, Hong K, Do JT. (2020. 2. 1). Comparative analysis of the mitochondrial morphology, energy metabolism, and gene expression signatures in three types of blastocyst-derived stem cells. Redox Biology. 30:101437. doi: 10.1016/j.redox.2020.101437.

Lee JE, Seo BJ, Han MJ, Hong YJ, Hong K, Song H, Lee JW, Do JT. (2020. 1. 28). Changes in the expression of mitochondrial morphology-related genes during the differentiation of murine embryonic stem cells. Stem Cells International. Volume 2020. Article ID: 9369268. doi: 10.1155/2020/9369268.

Gurunathan S, Jeyaraj M, La H, Yoo H, Choi Y, Do JT, Park C, Kim JH, Hong K. (2020. 1. 9). Anisotropic Platinum Nanoparticle-Induced Cytotoxicity, Apoptosis, Inflammatory Response, and Transcriptomic and Molecular Pathways in Human Acute Monocytic Leukemia Cells. International Journal of Molecular Science. 21(2): pii: E440. doi: 10.3390/ijms21020440.

Yoo H, Lee YJ, Park C, Son D, Choi DY, Park JH, Choi HJ, La HW, Choi YJ, Moon EH, Saur D, Chung HM, Song H, Do JT, Jang H, Lee DR, Park C, Lee OH, Cho SG, Hong SH, Kong G, Kim JH, Choi Y, Hong K. (2020. 1. 6). Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function. Cell Death & Disease. 11(1):14. doi: 10.1038/s41419-019-2201-1.

 

 
   
 
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